HEALTHY LONGEVITY MEDICINE

LEADERSHIP FOR EXPLORING SUSTAINABLE HEALTH.

HEALTHY LONGEVITY MEDICINE FOR ALL

THE HEALTHY LONGEVITY CHALLENGE – CLOSING THE GAP BETWEEN HEALTHSPAN AND LIFESPAN

“FIRST be your own HEALTH CAPTAIN”

“FIRST be your own HEALTH CAPTAIN – for your Family, Friends, Colleagues and Employees in your Community as an Role Model for Healthy Longevity and as Concerend Citizen for sustainable value-based Healthcare in your Town, your Region, on your Island”:

THE HEALTH CAPTAINS CLUB Leadership is focused on all perspectives towards the “SuperConvergence” developed by Eric Topol with the Horizon of 360-Degree value-based Innovations and new Technologies for Medicine 4.0 & Care 4.0 to support the Next Generations for the Future of Medicine & Innovation for “Healthy Longevity for All” to expand the Healthspan for everybody.

The Transformation from “SickCare” in “Silos” towards sustainable “LifeCare” in “Ecosystems” seem to be without alternative:

“By 2030, for the first time in recorded history, the old will begin to outnumber the young. NAM 2023.”

“This demographic shift poses significant social, economic, and health challenges, but also presents an unprecedented opportunity for accelerating research, innovation, and entrepreneurism in the field of healthy longevity – thereby building more vibrant societies and economies worldwide.

Healthy longevity means maintaining physical, mental, and social health and well-being as we live longer. By extending the healthspan, people can stay active in their families and communities, remain in the workforce and contribute to the economy, and enjoy fulfilling and productive lives well into their later years.” Source: NAM – National Academy of Medicine 2023 @ #HealthyLongevityChallenge

Introduction

Traditional medicine focus on disease: Healthcare as we know it around the globe over the last decades is a “disease-reactive” Healthcare Business and “siloed” Health Sciences Industry. 20^th Century Medicine has approached Health from the perspective of individual diseases in silos: In clinical medicine, in biomedical research, in drug development and many more fragmented and subspecialized medical fields. Typically medicine waits till people are sick with one or more diseases and then the system optimally try to cure those diseases but in reality what we end up doing is treating the symptoms in organs most of the time. Medicine has been successful in keeping sick people alive and the healthcare systems have been less successful at keeping people healthy. This is the fundamental challenge to transform “Sickcare” caused by Imprecison Medicine [7, 8] with the increasing “Sickspans” over the last decades towards sustainable biology and molecular based medicine for sustainable health to expand the healthspan on the individual and population health level (Precision Health). The expansion of the lifespan during the last 150 years opened the gap between lifespan and healthspan dramatically and our classic disease-reactive Healthcare Systems will collaps soon or later by the acceleration of the demographic shift limited by the power of our national economies: “By 2030, for the first time in recorded history, the old will begin to outnumber the young“ as the National Academy of Medicine stated to start the grand global Healthy Longevity Challenge in 2023 [1, 2, 3, 4].

Targeting Aging is 21th Century Medicine

The biological aging processes are the “mother of all diseases”: “Targeting Aging is 21st Century Medicine” – closing the gap between Lifespan and Healthspan for All is the paradigm shift [15]. Aging is the greatest risk factor for disease, e.g.

• Arthritis
• Cancer
• Kidney Disease
• Cardiovascular Disease
• Autoimmune Disorders
• Type II Diabetes
• Immune Decline
• Cognitive Decline

The biology of aging is well described and the Hallmarks of Aging are an summarizing molecular and biological interdependend concept:

The Hallmarks of Aging

Biological aging processes are characterized by a progressive loss of physiological and molecular integrity, leading to impaired function and increased vulnerability to the full spectrum of diseases and finally death.  Aging research has experienced an unprecedented advance over recent years, particularly with the discovery that the rate of aging is controlled, at least to some extent, by genetic pathways and biochemical processes conserved in evolution. The hallmarks of biological aging are described are: 1. Genomic instability, 2. telomere attrition, 3. epigenetic alterations, 4. Loss of proteostasis, 5. disabeled macroautophagy, 6. deregulated nutrient sensing, 7. mitochondrial dysfunction, 8. cellular senescence, 9. stem cell exhaustion, 10. altered intercellular communication, 11. chronic inflammation, 12. dysbiosis [11, 12]. Aging is driven by these 12 hallmarks fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them. These hallmarks are interconnected among each other, as well as to the recently proposed hallmarks of health, which include organizational features of spatial compartmentalization, maintenance of homeostasis, and adequate responses to stress. [11, 12]

The interdependence of aging hallmarks means that the experimental accentuation or attenuation of one specific hallmark usually affects other hallmarks as well. This underscores the fact that aging is a complex process that has to be conceived as a whole. Accordingly, each of the hallmarks should be considered as a point-of-entry for future exploration of the aging process, as well as for the development of new anti-aging medicines. Fig. 1 [4, 5, 11, 12]

The 5 Pillars of Healthy Longevity

Overview of the key pillars for sustainable Healthy Longevity, all with positive impact on the expansion of the Healthspan to decrease the Sickspan:

1. Healthy Exercise empowered by being your own Health Captain
2. Healthy Nutrition empowered by being your own Health Captain
3. Healthy Sleep empowered by being your own Health Captain
4. Mental, Emotional and Social Healthy Longevity empowered by THE HEALTH CAPTAINS CLUB Grand Salons for Healthy Longevity to scale meaningful Togetherness to positively inspire your 100 Billion Braincells by Input out of Music, Art, Medicine, Science, Philosophy, Literature, History, Entrepreneurship, Innovation and new Technologies as Source of sustainable SYNAPTING of your about 10.000 Synapsis of each of your about 100 Billion Braincells.
5. Healthy Longevity Medicine empowered by molecular Hallmarks of Aging, Biological Clock and Precision Health Diagnostics to optimize individually the Healthy Longevity Pillars 1.-4. and to tailor additional Precision Health Interventions to the Individual “n-of-1” in Healthy Longevity Medical Centers powered by Academic Medical Centers with the Result in the coming years and decades to expand the Healthspan about 10 to 20 to even 30 more Years – reflect on and prepare the Purpose of your Life after the Age of 60-70 Years up to 100 Healthy Years:

“First be your own Health Captain, for your Family, for your Friends, for your Colleagues, for your Employees in your Community as a Role Model for Healthy Longevity” – welcome on Board as a Member of THE HEALTH CAPTAINS CLUB for more access towards Healthy Longevity Knowledge and Healthy Longevity Communities – more @ https://healthcaptains.club :

The fundament for Healthy Longevity seems to be long term healthy social relationships as the „Harvard Study of Adult Development“, which started over 80 years ago, describes loneliness as one of the most powerful killers and „The people who were the most satisfied in their relationships at age 50 were the healthiest at age 80.” [14]

Holistic Brain Health should be the basic key towards Healthy Longevity to give the other pillars more substance and effective power to expand the healthspan.

By the Definition of Healthy Longevity Medicine Society “Healthy Longevity Medicine is optimizing healthspan by targeting ageing processes across the lifespan“ [3, 4]. Healthy Longevity at scale needs therefore the self-navigation of Exercise, Nutrition, Sleep and 360º Brain Health. All these pillars needs more basic science and direct knowledge transfer towards the medical communities and societies at the same level:

„The Health Captain will be the CEO of his own Health by navigating his Healthy Longevity with his fingertips on his smartphone to expand his individual Healthspan over Lifetime“ [7, 8, 9]

Fig 1: The Hallmarks of Aging are fulfilling the following three premises: (1) their age-associated manifestation, (2) the acceleration of aging by experimentally accentuating them, and (3) the opportunity to decelerate, stop, or reverse aging by therapeutic interventions on them – Source: 2013 and 2023 in Cell. [11, 12]

Healthy Longevity Medicine for All is based on scaleable Precision Health

The current „Taxonomy of Medicine“ is a barrier to progress (Source: Keith R. Yamamoto, UCSF, USA):

• Descriptive: Disease classifictaion is based predominantly on symptoms and organs.
• Inflexible: Creates rigid silos in research, diagnosis & therapy, education and funding.
• Narrow: No natural fit for new fundamental discoveries; no rationale for building continium of research and clinical care.
• Not sustainable: The Hallmarks of Aging – the Biology of Aging as greatest riscfactor for disease is not part of the current taxonomy – a new symbosis of an integrated taxonomy of disease and health is the basis for scaleable Precsion Health for All

Don’t forget that the “normal” Biology is complicated, therefore the hallmarks of aging, as a deviation from health, and the biology of disease are similary complex. We need an integrated understanding of the new multiple molecular levels and the “traditional” levels of medicine and the integration of the hallmarks of aging to deeply understand the individual disease and health status on multiple levels to bring tailored Healthy Longevity diagnostic n =1 and Healthy Longevity therapeutic interventions n =1 to the individual to expand the Healthspan for All. The traditional „one-fits-all“ disease reactive pharma concept delivers value only to a small subgroup of patients – this Imprecision Medicine is absolutly non-ethical in our modern societies and damages the lives of patients and national economies in the billions of dollars [7, 12, 15]:

Today medicine is moving through an Inflection Point from „Sickcare“ in „Silos“ towards „Lifecare“ in scaleable „Ecosystems“ based on the Super Convergence in the cross-over of InfoTech and BioTech. Based on technology and synchronically by integrating and developing a working continuum to create a Precision Health value-chain:

• The Integration: Aggregate and analyze biological information, incorporating concepts and technologies of physical sciences, engineering and computer science
• The Working Continuum: From fundamental discovery, to translation, to clinical research, to clinical practice, to citiziens – „from bench to bedside & from bedside to bench and towads society and industry“
• The Super Convergence: From Imprecision to Precision Medicine [7, 9, 10] – Eric Topol 2013 „The Creative Destruction of Medicine – How the digital revolution will create better healthcare“ [13]

The Precision Health Value-Chain for Healthy Longevity and the Big-Data Challenge

The digital-molecular Transformation of Medicine towards Healthy Longevity Medicine in the transformation of “Sickcare” towards “Lifecare” is creating a new multi-stakeholder value-chain for a sustainbale Healthy Longevity Industry.

• Precision Health for Healthy Longevity will aggregate, integrate and analyze biological information, drawing on vast collections of data to produce health advice and predictions, and Hallmarks of Aging inculding disease Diagnosis, tailored to the Individual
• Precision Health for Healthy Longevity will be enabled by computional Information Commons, within which correlations produce a Knowledge Network, generating new hypothesis, illuminating mechanisms of disease and the Hallmarks of Aging, and establishing links between the hallmarks and diseases thought to be unrelated
• Precision Health for Healthy Longevity will revolutionize development and deployment of therapies and healthy longvity medicine interventions, as well as principles of clinical practice, by allowing all stakeholdres to benefit from and participate in the research data, health data and health industry data sets

This multilayer Precision Health Value-Chain needs in the long run for scaling sustainable Health the Synchronization of some hundreds of Academic Public Hospital Providers on an scaleable international Platform to share the Knowledge-Network like an Information Common in an certified democratic value-based open source system together to deliver this individualizable medical and health information to every patient needed – by dataethics rules there should be no limitation to access to medical information in the age of Precision Health. [7, 10]

Precision Health for Healthy Longevity Medicine will be organized in database-layers

Today like in Google Maps every patient needs to be for an accurate diagnosis digitized in several molecular levels (genomics, transcriptomics, epigenomics, mircobiomics, exposome, biomarkers of aging) [6] – Fig 2. Precision Health for Healthy Longevity takes individual variation into account: variation in our genes, environment, lifestyle, hallmarks of aging and even in the microscopic organisms that are living inside of us. “The best chance of favorable outcome is getting the initial health intervention to expand the healthspan after molecular individual diagnosis of age related biomarkers right.”: Precision Health for Healthy Longevity First. [5, 7]

Fig 2: “Towards Precision Medicine”, Source: National Academy of Sciences (USA) 2011 [6]

Beyond the genome and the biomarker measurement of the molecular hallmarks of aging: Understanding how genetic variations contribute to health is just one aspect of Precision Health. While the genome is set for life, the expression of our genes fluctuates over time and in response to the environment. Additional approaches to Precision Health involve measuring levels of proteins, RNAs, or metabolic products, biomarkers of aging. Along with genomics, proteomics, epigenomics, and metabolomics can help inform medical choices for individual patients. The field also incorporates what we are learning about the microbes that live in and on our bodies and how they can be manipulated to influence health and disease. [7, 11, 12]

Beyond targeting aging in diagnostics and therapy, Precision Health includes approaches to diagnostics, extremely early prevention, and screening of health:

• Methods for identifying those who are at risk before disease strikes;
• Analytical tools for predicting which prevention strategies will work best for which patients;
• Screening methods that can identify early signs of disease before symptoms emerge;
• Diagnostic methods for identifying subtypes of disease that may look the same on the surface but respond very differently to treatment;
• Tests that can identify disease carrier status for prospective parents;
• Devices for managing diseases and for tracking and guiding recovery

High performing Precision Health Ecosystems will reduce healthcare costs. To achieve this Tipping Point in the transformation process the leadership of all stakeholders is needed to save our national health economies, our civilizations and our ethical believe-systems.

Continuing on the level of permanently rising healthcare costs caused by Imprecise Medicine and “Sickcare” will soon or later lead to the collapse all our healthcare systems worldwide. Towards Precision Health for Healthy Longevity Medicine is a fundamental transformation of healthcare politics, national health economics and the traditional business models of the „old“ stakeholders in the healthcare industry that will need to change [7, 15].

The key driving force towards value-based Precision Health for Healthy Longevity for All are our patients by democratization of health information on their fingertips via smartphones towards a totally transparent medicine. We have to measure the medical outcomes in a global standardized setting – this is key in Precision Health and start to implement Precision Health for Healthy Longevity in Academic Medical Center Networks:

Precision Health Longevity Departments at Public Academic Medical Centers

As Healthy Longevity Medicine powered by Precision Health is a new holistic Medical Specialty field Longevity Departments for scaleable Precision Health should be anchored in Public Academic Medical Centers to integrate these 4 Pillars:

1. P1: Academic Medical Center Healthy Longevity Clinical Center
2. P2: Academic Medical Center Healthy Longevity Research Center
3. P3: Academic Medical Center Healthy Longevity Innovation Hub
4. P4: Academic Medical Center Healthy Longevity Education Hub

Since 2023 we see the first openings of Healthy Longevity Medical Centers inside Academic Medical Centers towards Healthy Longevity for All. These new Healthy Longevity Departments inside University Medical Centers act on an international level together to exchange knowledge and to create synchronized standards for an scaleable Healthy Longevity together with Academic Healthy Longevity Research Centers like the Buck Institute in California. Prototypes for this new kind of academic anchored Healthy Longevity Medicine are the National University of Singapore and the Sheba Medical Center in Tel Aviv beyond others.

The Healthy Longevity Department at Sheba Medical Center is based on their “4A”-Strategy which should be the Healthy Longevity Department Fundament at all Academic Medical Centers at scale:

A1: Accesible: Healthy Longevity Clinics in Public Academic Medical Centers

A2: Affordable: Healthy Longevity for All

A3: Academic: P1. Clinical Hub P2. Research Hub P3. Innovation Hub P4. Education Hub

A4: Artificial Intelligence: Big Data Driven in Knowledge Networks and Information Commons

The political will of the Government in Singapore is to expand the Heathspan by plus 3 years in the next 10 years. Though Singapore is just the blueprint for the beginning transformation towards 360º Next Generation Life Care and because of the beginning and accelerating collapse of sickcare more governments and national economies will follow to close the Gap between Healthspan and Lifespan:

Closing the Gap between Healthspan and Lifespan

Research has shown that healthspan is more valuable economically and personally than is lifespan [15]. Using a value of statistical life economic model (which places a monetary value on gains from longer life, better health and changes in the rate of aging), Scott et al.  found that compressing the period of morbidity to improve health in older age was more valuable than further increases in life expectancy [15]: “The economic value of gains from an extra year of healthy life expec­tancy always exceeded those from an extra year of life expectancy”. Targeting biological aging instead of individual diseases offered potentially larger economic gains than eradi­cating individual diseases, with an attenua­tion of aging that increased life expectancy by 1 year being worth $38 trillion [15].

Though closing the gap between healthspan and lifespan is critical for our national economies and will be one of the main drivers for the transformation from „Sickcare“ towards „Lifecare“ to increase the Healthspan to decrease the Sickspans at the same time.

The Healthy Longivity Industry resonates with the idea of a 360-degree One-Health-Concept (OHC) including Blue Zone Care and One Health Life Care. Instead of expanding the market for sickcare, we must invest in lifecare as strategic assets from the micro-, meso- and macro-level to overcome the obstacles and constraints of sick caring institutions which brings our national economies towards a collapse instead of creating together a new sustainable multi-trillion Healthy Longevity Industry worldwide.

This transformation will bring the biggest industry of all times to birth and has additional effects by the value-based convergence of Healthy Longevity, Blue Zone Community Care and One Health Life Care:

Healthy Longevity Medicine, Blue Zone Community Care and One Health Life Care are interdependend and are an next level Academic Convergence Challenge

In the field of 360º Next Generation Lifecare in Human Medicine the professional community is aware that the hughes parallelity of innovations areas happening at the same time are interdependent and therefore the industry is createing a “superconvergence” driven by the growing innovations horizon towards new technologies in the transformation of the outdated locally, regional and national siloed disease-reactive healthcare systems towards sustainable lifecare by integrating Healthy Longevity [3], Blue Zone Community Care [22] and One Health Life Care [16] in international medical ecosystems based on scaleable platforms towards a multi-trillion healthy longevity industry [15].

Blue Zone Community Care – A Blue Zone is a region in the world where people are claimed to have exceptional long healthy lives and many centenarians with compressed morbidity due to a lifestyle combining physical activity, low stress, rich social interactions, a local whole-foods diet, and low disease incidence as found in the Blue Zones in Okinawa Island (Japan), Sardinia Island (Italy), Nicoya (Costa Rica), Icaria Island (Greece) and Loma Linda (California) [22].

Blue Zone Community Care is a new public health concept to create new Blues Zones Communities by combining the knowledge out of the classic Blue Zones, Healthy Longevity for all and One Health:

One Health is built on a simple understanding – that human health, animal health and our shared environment are part of a deeply interconnected system. Healthy Longevity Medicine [and Blue Zone Community Care can be understood as an additional integral part to add towards the „One Health Umbrella“ – Fig. 3 [16, 17, 18, 19, 20, 21].

In One Health Life Care and additionally Healthy Longevity Medicine and Blue Zone Community Care we are still missing convergence strategies because fully different to human healthcare with e.g. hundreds of university hospitals and thousands of academic research institutions globally as 360º Next Generation Healthcare Transformation Hubs“from bench to bedside and bedside to bench” running established innovation and education cycles and thousands of start-up`s in every innovation field we are missing to start with real combined One Health Life Care – Healthy Longevity – Blue Zone Community Care Research Institutions and One Health Innovation Technology Parks to support One Health Innovations and to create new Business Models for an real value-based One Health Industry.

One Health Life Care as Healthy Longevity and Blue Zone Community Care are still not established in the academic institutional training of doctors, veterinarians and the additionally many environmental and planetary and blue zone health scientific fields as a whole. The missing One Health Education and Research strategies of national and international universities is the missing link towards new One Health Innovations and new One Health Business Platforms. Still we see the investment in One Health Education as the key factor to open this transdisciplinary field towards new sustainable Health Business beyond the upcoming Healthy Longevity Industry. [6, 8, 16, 22]

This article should inspire the community to take action by becoming a Member of THE HEALTH CAPTAINS CLUB and we are looking forward to make it happen together. [9]

Welcome on Board!

Without the breakthrough in the Convergence Challenge of Academic Institutions One Health in the combination with Healthy Longevity Medicine and Science combined with sustainable Healthcare and Blue Zone Community Care  as scientific and strategic approach remains far to much in the theoretical field. This article is an authentic call of action towards the whole community to built an new sustainable Health Industry at scale for the next generations to come.

University Medical Center, Academic Medical Center and Health Foundations should take the Leadership together for this convergence to create new health sciences, integrated research and education surrounded by new start-up champions to create a new international sustainable Health Industry. The Author opened therefore THE HEALTH CAPTAINS INSTITUTE to unit Academic Medical Centers and Health Foundations for synchronized Strategy Studies and to anchor Precision Health for Healthy Longevity, Precision Medicine for sustainable Healthcare, Blue Zone Community Care and One Health Life Care as academic convergence platform to create the momentum together. Looking forward and welcome on Board:

“OUR GREATEST RESPONSIBILITY IS TO BE GOOD ANCESTORS.”  – Jonas Salk

References:

[1]     National Academy of Medicine – The Global Road Map for Healthy Longevity published 2023 DOI: https://nam.edu/initiatives/grand-challenge-healthy-longevity/global-roadmap-for-healthy-longevity/

[2]     The Grand Global Healthy Longevity Challenge published 2023 DOI: https://healthylongevitychallenge.org/about-us/

[3]     The Healthy Longevity Medicine Society Healthy Longevity Medicine Definition published 2022 DOI: https://hlms.co

[4]     Is ageing a disease? Editorial of The Lancet Healthy Longevity VOLUME 3, ISSUE 7, E448, JULY 2022 – Open Access Published: July, 2022 DOI: https://doi.org/10.1016/S2666-7568(22)00154-4

[5]     Zhavoronkov, A., Bischof, E. & Lee, KF. Artificial intelligence in longevity medicine. Nat Aging 1, 5–7 (2021). https://doi.org/10.1038/s43587-020-00020-4

[6]     National Research Council (2011) Towards Precision Medicine: Building a knowledge network for  biomedical research and a new taxonomy of disease. National Academies Press Washington, DC. URL: www.nap.edu/catalog/13284/toward-precision-medicine- building-a-knowledge-network-for- biomedical-research

[7]     von Blanquet HM (2019) Creating Solutions for Value-based Precision Medicine. In: Pieper U, Steidel A, Werner J (Eds.) XPOMET 360-Degree Next Generation Healthcare, Medizinisch Wissenschaftliche Verlagsgesellschaft Berlin.

[8]     von Blanquet HM (2022) Präzisionsmedizin als Basis individueller Patientensicherheit In: Gausmann P et. al. (Ed.) Patientensicherheitsmanagement, Walter de Gryter Berlin

[9]     von Blanquet HM (2023) Precision Medicine und Systemmedizin-Plattformen In: Matusiewicz D Martin A (Eds.) Smarte Medizin, hogrefe Bern

[10]   Eric J. Topol, Individualized Medcine from Prewomb to Tomb, Cell Volume 157, Issue 1, 27 March 2014, Pages 241-253

[11]   Carlos Lo ́ pez-Otı ́n, Maria A. Blasco, Linda Partridge, Manuel Serrano, and Guido Kroemer, Hallmarks of Aging, Cell Volume 153, Issue 6, PAGES 1194-1217, JUNE 06, 2013

[12]   Carlos Lo ́ pez-Otı ́n, Maria A. Blasco, Linda Partridge, Manuel Serrano, and Guido Kroemer, Hallmarks of Aging: An expanding universe, Cell Volume 186, Issue 2, PAGES 243-287, JANUARY 19, 2023

[13]   Topol EJ (2013) The Creative Destruction of Medicine – How the digital revolution will create better healthcare.Basic Books New York

[14]   Harvard Study of Adult Development 1938-2022 DOI: https://www.adultdevelopmentstudy.org

[15]   Khan, M., Al Saud, H., Sierra, F. et al. Global Healthspan Summit 2023: closing the gap between healthspan and lifespan. Nat Aging 4, 445–448 (2024). https://doi.org/10.1038/s43587-024-00593-4

[16]   von Blanquet HM, Friebe M (2022) Navigating towards a Future of One Health In: Friebe M  (Ed.) Novel Innovation Design for the Future of Health: Entrepreneurial Concepts for Patient Empowerment and Health Democratization, Springer Berlin – Heidelberg – New York

[17]   The One Health Approach-Why Is It So Important?. Mackenzie JS, Jeggo M. Trop Med Infect Dis. 2019;4(2):88. Published 2019 May 31. doi:10.3390/tropicalmed4020088

[18]   Core Competencies in One Health Education: What Are We Missing? Togami E, Gardy JL, Hansen GR, Poste GH, Rizzo DN, Wilson ME, and Mazet JAK. 2018. NAM Perspectives. Discussion Paper,National Academy of Medicine, Washington, DC. https://doi.org/10.31478/201806a.

[19]   One Health Core Competency Domains, Frankson R, Hueston W, Christian K, Olson D, Lee M, Valeri L, Hyatt R, Annelli J, and Rubin C, Front Public Health,2016;4:192, Published Sep13, 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5020065/

[20]   Incorporating One Health into Medical Education, Rabinowitz PM, Natterson-Horowitz BJ, Kahn LH, Kock R, Pappaioanou M, BMC Medical Education. 2017 Feb 23; 17: 45 https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909-017-0883-6

[21]   A framework to promote collective action within the One Health community of practice: Using participatory modelling to enable interdisciplinary, cross-sectoral and multi-level integration, Binot A, Duboz R, Promburom P, Phimpraphai W, CappeleJ, Lajaunie C, Goutard FL, Pinyopommintr T, Fiquie M, Roger FL, One Health. 2015 Sep 13;1:44-48. eCollection 2015 Dec. https://www.ncbi.nlm.nih.gov/pubmed/28616464

[22]   Buettner D, Skemp S. Blue Zones: Lessons From the World’s Longest Lived. Am J Lifestyle Med. 2016 Jul 7;10(5): 318-321 – DOI: 10.1177/1559827616637066. PMID: 30202288; PMCID: PMC6125071.

Based on our Neuroleadership-Knowledge we bring together max. 50 transdisciplinary Participants from the Expert- and Leadership-Level to multi-stakeholder mixed Brainpools in the different fields of Innovation:

• Genomics, Transcriptomics, Proteomics, Metabolomics, Microbiomics, Epigenomics
• Pharmagenomics and „in-silico“ Medicine
• Global Human Cell Atlas based on Single-Cell Sequencing
• Precision Medicine & Precision Science
• Biomarkers and Biochips
• Digital Imaging
• Digital Information and Knowledge Systems
• Wireless Sensors
• Mobile Connectivity (5G) & Wireless Communication Technologies
• GPS in Healthcare
• Internet of Things (IoT)
• Social Media Networks
• Increasing performance of Computers and Smartphones
• Wearable Computing and Communication
• Increasing performance of databases for Big and Smart Data
• BIG DATA and Analytics
• Cloud and Mobile Computing
• Artificial Intelligence
• Cybersecurity
• Data Privacy and Data Ethics
• Blockchain Technology
• Health Apps
• Regenerative Medicine
• Smart Implants
• Breakthrough Materials
• 3D-Printing and Bioprinting
• Robotics
• Cyborgs
• Exoskeleton
• Smart Glasses
• Virtual and Augmented Reality
• Nanomedicine
• Telehealth
• Medical Drones
• CRISPR
• Smart Education
• Smart Hospital
• Future Living
• One Health
• Blue Zones
• Healthy Longevity

THE HEALTH CAPTAINS CLUB Strategy is focused on the acceleration of the implementation of value-based innovations and to close the innovation-cycle:

“from bench to bedside and from bedside to bench”

#Video 1 – Eric Topol: The Future of Medicine

#Video 2 – Matt Kaeberlein: Overview on Healthy Longevity 

#Video 3 – Eyal Zimlichman: The Future of Health and Hospitals without addresses

#SustainableHealth & #SustainableHealthcare

World Health Summit: Perspectives on sustainable Health